{"id":8645,"date":"2024-06-01T13:01:01","date_gmt":"2024-06-01T05:01:01","guid":{"rendered":""},"modified":"2024-06-01T13:01:01","modified_gmt":"2024-06-01T05:01:01","slug":"\u836f\u6548\u56e2\u6a21\u578b\u6784\u5efa_\u6307\u6807\u4f53\u7cfb\u7684\u6784\u5efa\u65b9\u6cd5","status":"publish","type":"post","link":"https:\/\/mushiming.com\/8645.html","title":{"rendered":"\u836f\u6548\u56e2\u6a21\u578b\u6784\u5efa_\u6307\u6807\u4f53\u7cfb\u7684\u6784\u5efa\u65b9\u6cd5"},"content":{"rendered":"
<\/p>\n
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<\/p>\n 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Catalyst)\u4ec5\u4ec5\u53ea\u8003\u8651\u836f\u7269\u5206\u5b50\u4e2d\u6700\u5e38\u89c1\u7684\u6c22\u952e\u53d7\u4f53\u5f62\u5f0f\uff0c\u5305\u62ec\uff1a<\/p>\n A. sp\u6216sp2\u6742\u5316\u7684\u6c27\u539f\u5b50 B. \u4e0e\u78b3\u539f\u5b50\u4ee5\u53cc\u952e\u5f62\u5f0f\u76f8\u8fde\u7684\u786b\u539f\u5b50 C. \u4e0e\u78b3\u539f\u5b50\u4ee5\u53cc\u952e\u6216\u4e09\u952e\u76f8\u8fde\u7684\u6c2e\u539f\u5b50<\/p>\n \u6c22\u952e\u7ed9\u4f53\u4e3b\u8981\u5305\u62ec\u6c22\u539f\u5b50\u4ee5\u53ca\u4e0e\u4e4b\u76f8\u8fde\u7684\u6c27\u539f\u5b50\u548c\u6c2e\u539f\u5b50,\u4e00\u822c\u6709<\/p>\n A.\u975e\u9178\u6027\u7f9f\u57fa B.\u6c28\u57fa C.\u6b21\u6c28\u57fa,\u4f46\u4e0d\u5305\u62ec\u4e09\u6c1f\u7532\u57fa\u78fa\u9170\u80fa\u548c\u56db\u5511\u4e2d\u7684\u6b21\u6c28\u57fa\u3002<\/p>\n 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Studio\u8f6f\u4ef6\u5305\u4e2d\u6c22\u952e\u7ed9\u4f53(\u7d2b\u8272)\u548c\u6c22\u952e\u53d7\u4f53(\u7eff\u8272)\u7279\u5f81\u7684\u793a\u610f\u56fe\u3002\u5728\u6bd4\u8f83\u4e00\u4e2a\u836f\u6548\u56e2\u548c\u6d4b\u8bd5\u5206\u5b50\u4e2d\u7684\u6c22\u952e\u7279\u5f81\u65f6\uff0c\u4e0d\u4ec5\u8981\u6bd4\u8f83\u6c22\u952e\u7279\u5f81\u7684\u4f4d\u7f6e\uff0c\u8fd8\u9700\u8981\u6bd4\u8f83\u6c22\u952e\u7279\u5f81\u7684\u77e2\u91cf\u65b9\u5411\u3002<\/p>\n<\/p>\n <\/p>\n 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\u4e8c\u3001\u836f\u6548\u7279\u5f81\u5143\u7d20\u5b9a\u4e49<\/h2>\n
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(\u4e00) \u6c22\u952e\u53d7\u4f53<\/h3>\n
(\u4e8c) \u6c22\u952e\u7ed9\u4f53<\/h3>\n
(\u4e09) \u758f\u6c34\u4e2d\u5fc3<\/h3>\n
(\u56db) \u82b3\u73af\u4e2d\u5fc3<\/h3>\n
(\u4e94) \u7535\u8377\u4e2d\u5fc3<\/h3>\n
\n
\n
(\u516d) \u6392\u65a5\u4f53\u79ef<\/h3>\n
(\u4e03) \u836f\u6548\u7279\u5f81\u7684\u51e0\u4f55\u7ea6\u675f<\/h3>\n
\u4e09\u3001\u5e94\u7528<\/h2>\n
\n
\u56db\u3001\u836f\u6548\u56e2\u6784\u5efa<\/h2>\n
\u4e94\u3001Discovery studio \u591a\u79cd\u521b\u5efa\u836f\u6548\u56e2\u6a21\u578b\u65b9\u6cd5<\/h2>\n
3D OSAR Pharmacophore Generation<\/h3>\n
Steric Refinement with Excluded Volumes<\/h3>\n
Auto Pharmacophore Generation\uff08\u4ece\u5355\u4e2a\u914d\u4f53\u751f\u6210\u4e00\u7ec4\u9009\u62e9\u6027\u836f\u6548\u56e2\u6a21\u578b\uff09<\/h3>\n
Interaction Pharmacophore Generation\uff08\u751f\u6210\u975e\u952e\u76f8\u4e92\u4f5c\u7528\u836f\u6548\u56e2\u6a21\u578b\uff09<\/h3>\n
Common Feature Pharmacophore Generation\uff08\u4ece\u4e00\u7ec4\u914d\u4f53\u751f\u6210\u5171\u540c\u7279\u5f81\u836f\u6548\u56e2\u6a21\u578b\uff09<\/h3>\n
HipHop\u662f\u4e00\u79cd\u7528\u4e8e\u8bc6\u522b\u5148\u5bfc\u5316\u5408\u7269\u8f93\u5165\u96c6\u4e2d\u5e38\u89c1\u836f\u6548\u56e2\u7279\u5f81\u7684\u7a0b\u5e8f\u3002\u6700\u591a32\u4e2a\u914d\u4f53\u3002<\/p>\n<\/p>\nEnsemble Pharmacophore Generation\uff08\u751f\u6210\u96c6\u5408\u836f\u6548\u56e2\u6a21\u578b\uff09<\/h3>\n
1.\u8f93\u5165\u6d3b\u6027\u914d\u4f53\u4f7f\u7528\u836f\u6548\u56e2\u6307\u7eb9\u805a\u7c7b<\/p>\n