{"id":8979,"date":"2024-05-18T20:01:01","date_gmt":"2024-05-18T12:01:01","guid":{"rendered":""},"modified":"2024-05-18T20:01:01","modified_gmt":"2024-05-18T12:01:01","slug":"\u86cb\u767d\u8d28\u7ed3\u6784\u4e0e\u529f\u80fd\u7684\u9884\u6d4b\u65b9\u6cd5\u603b\u7ed3\u548c\u8d44\u6599\u6c47\u603b","status":"publish","type":"post","link":"https:\/\/mushiming.com\/8979.html","title":{"rendered":"\u86cb\u767d\u8d28\u7ed3\u6784\u4e0e\u529f\u80fd\u7684\u9884\u6d4b\u65b9\u6cd5\u603b\u7ed3\u548c\u8d44\u6599\u6c47\u603b"},"content":{"rendered":"<p><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" style=\"display: none;\"> \n <path stroke-linecap=\"round\" d=\"M5,0 0,2.5 5,5z\" id=\"raphael-marker-block\" style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);\"><\/path> \n<\/svg> <\/p>\n<p>\u86cb\u767d\u8d28\u7ed3\u6784\u4e0e\u529f\u80fd\u7684\u9884\u6d4b\u65b9\u6cd5\u603b\u7ed3\u548c\u8d44\u6599\u6c47\u603b<\/p>\n<p><strong>\u201c\u6298\u53e0\uff08fold\uff09\u201d\u7684\u6982\u5ff5<\/strong><br \/> 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<strong>\u6309\u7167\u6784\u8c61\u53c2\u6570\u503c\u7684\u5927\u5c0f\u53ef\u4ee5\u628a\u6c28\u57fa\u9178\u5206\u4e3a\u516d\u4e2a\u7ec4<\/strong>\uff1aHa\uff08\u5f3a\u87ba\u65cb\u5f62\u6210\u8005\uff09\u3001ha\uff08\u87ba\u65cb\u5f62\u6210\u8005\uff09\u3001Ia\uff08\u5f31\u87ba\u65cb\u5f62\u6210\u8005\uff09\u3001ia\uff08\u87ba\u65cb\u5f62\u6210\u4e0d\u654f\u611f\u8005\uff09\u3001ba\uff08\u87ba\u65cb\u4e2d\u65ad\u8005\uff09\u3001Ba\uff08\u5f3a\u87ba\u65cb\u4e2d\u65ad\u8005\uff09\u3002<br \/> Chou\u548cFasman\u6839\u636e\u6b8b\u57fa\u7684\u503e\u5411\u6027\u56e0\u5b50\u63d0\u51fa\u4e8c\u7ea7\u7ed3\u6784\u9884\u6d4b\u7684\u7ecf\u9a8c\u89c4\u5219\uff0c\u8981\u70b9\u662f<strong>\u6cbf\u86cb\u767d\u5e8f\u5217\u5bfb\u627e\u4e8c\u7ea7\u7ed3\u6784\u7684\u6210\u6838\u4f4d\u70b9\u548c\u7ec8\u6b62\u4f4d\u70b9\u3002<\/strong><br \/> 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\u8fd9\u6837\u4f7f<strong>\u9884\u6d4b\u7684\u6210\u529f\u7387\u63d0\u9ad8\u5230 65% \u5de6\u53f3<\/strong>\u3002GOR\u65b9\u6cd5\u7684<strong>\u4f18\u70b9\u662f\u7269\u7406\u610f\u4e49\u6e05\u695a\u660e\u786e\uff0c\u6570\u5b66\u8868\u8fbe\u4e25\u683c\uff0c\u800c\u4e14\u5f88\u5bb9\u6613\u5199\u51fa\u76f8\u5e94\u7684\u8ba1\u7b97\u673a\u7a0b\u5e8f\uff0c\u4f46\u7f3a\u70b9\u662f\u8868\u8fbe\u5f0f\u590d\u6742\u3002<\/strong><\/p>\n<h3>\u591a\u5e8f\u5217\u5217\u7ebf\u9884\u6d4b<\/h3>\n<p><strong>\u5bf9\u5e8f\u5217\u8fdb\u884c\u591a\u5e8f\u5217\u6bd4\u5bf9\uff0c\u5e76\u5229\u7528\u591a\u5e8f\u5217\u6bd4\u5bf9\u7684\u4fe1\u606f\u8fdb\u884c\u7ed3\u6784\u7684\u9884\u6d4b<\/strong>\u3002\u8c03\u67e5\u8005\u53ef\u627e\u5230\u548c\u672a\u77e5\u5e8f\u5217<strong>\u76f8\u4f3c\u7684\u5e8f\u5217\u5bb6\u65cf<\/strong>\uff0c\u7136\u540e<strong>\u5047\u8bbe\u5e8f\u5217\u5bb6\u65cf\u4e2d\u7684\u540c\u6e90\u533a\u6709\u540c\u6837\u7684\u4e8c\u7ea7\u7ed3\u6784<\/strong>\uff0c\u9884\u6d4b\u4e0d\u662f\u57fa\u4e8e\u4e00\u4e2a\u5e8f\u5217\u800c\u662f\u4e00\u7ec4\u5e8f\u5217\u4e2d\u7684\u6240\u6709\u5e8f\u5217\u7684\u4e00\u81f4\u5e8f\u5217\u3002<\/p>\n<h3>\u57fa\u4e8e\u795e\u7ecf\u7f51\u7edc\u7684\u5e8f\u5217\u9884\u6d4b<\/h3>\n<p>\u5229\u7528\u795e\u7ecf\u7f51\u7edc\u7684\u65b9\u6cd5\u8fdb\u884c\u5e8f\u5217\u7684\u9884\u6d4b\uff0c<strong>BP \u7f51\u7edc\u5373\u53cd\u9988\u5f0f\u795e\u7ecf\u7f51\u7edc\u7b97\u6cd5\u662f\u76ee\u524d\u4e8c\u7ea7\u7ed3\u6784\u9884\u6d4b\u5e94\u7528\u6700\u5e7f\u7684\u795e\u7ecf\u7f51\u7edc\u7b97\u6cd5<\/strong>\u3002<br \/> \u5b83\u901a\u5e38\u662f<strong>\u7531\u4e09\u5c42\u76f8\u540c\u7684\u795e\u7ecf\u5143\u6784\u6210\u7684\u5c42\u72b6\u7f51\u7edc\uff0c\u4f7f\u7528\u53cd\u9988\u5f0f\u5b66\u4e60\u89c4\u5219<\/strong>\uff0c\u5e95\u5c42\u4e3a\u8f93\u5165\u5c42\uff0c\u4e2d\u95f4\u4e3a\u9690\u542b\u5c42\uff0c\u9876\u5c42\u662f\u8f93\u51fa\u5c42\uff0c\u4fe1\u53f7\u5728\u76f8\u90bb\u5404\u5c42\u95f4\u9010\u5c42\u4f20\u9012\uff0c\u4e0d\u76f8\u90bb\u7684\u5404\u5c42\u95f4\u65e0\u8054\u7cfb\uff0c<strong>\u5728\u5b66\u4e60\u8fc7\u7a0b\u4e2d\u6839\u636e\u8f93\u5165\u7684\u4e00\u7ea7\u7ed3\u6784\u548c\u4e8c\u7ea7\u7ed3\u6784\u7684\u5173\u7cfb\u7684\u4fe1\u606f\u4e0d\u65ad\u8c03\u6574\u5404\u5355\u5143\u4e4b\u95f4\u7684\u6743\u91cd\uff0c\u6700\u7ec8\u76ee\u6807\u662f\u627e\u5230\u4e00\u79cd\u597d\u7684\u8f93\u5165\u4e0e\u8f93\u51fa\u7684\u6620\u8c61<\/strong>\uff0c\u5e76\u5bf9\u672a\u77e5\u4e8c\u7ea7\u7ed3\u6784\u7684\u86cb\u767d\u8fdb\u884c\u9884\u6d4b\u3002<br \/> \u795e\u7ecf\u7f51\u7edc\u65b9\u6cd5\u7684<strong>\u4f18\u70b9\u662f\u5e94\u7528\u65b9\u4fbf\uff0c\u83b7\u5f97\u7ed3\u679c\u8f83\u5feb\u8f83\u597d\uff0c\u4e3b\u8981\u7f3a\u70b9\u662f\u6ca1\u6709\u53cd\u6620\u86cb\u767d\u7684\u7269\u7406\u548c\u5316\u5b66\u7279\u6027<\/strong>\uff0c\u800c\u4e14\u5229\u7528\u5927\u91cf\u7684\u53ef\u8c03\u53c2\u6570\uff0c\u4f7f\u7ed3\u679c\u4e0d\u6613\u7406\u89e3\u3002<br \/> <strong>\u8bb8\u591a\u9884\u6d4b\u7a0b\u5e8f\u5982PHD\u3001PSIPRED\u7b49\u5747\u7ed3\u5408\u5229\u7528\u4e86\u795e\u7ecf\u7f51\u7edc\u7684\u8ba1\u7b97\u65b9\u6cd5<\/strong>\u3002<\/p>\n<h3>\u57fa\u4e8e\u5df2\u6709\u77e5\u8bc6\u7684\u9884\u6d4b\u65b9\u6cd5\uff08knowledge based method\uff09<\/h3>\n<p>\u8fd9\u7c7b\u9884\u6d4b\u65b9\u6cd5\u5305\u62ec<strong>Lim \u548c Cohen \u4e24\u79cd\u65b9\u6cd5<\/strong>\u3002<br \/> <strong>Lim \u65b9\u6cd5\u662f\u4e00\u79cd\u7269\u7406\u5316\u5b66\u7684\u65b9\u6cd5<\/strong>\uff0c\u5b83<strong>\u6839\u636e\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\uff0c\u5305\u62ec\uff1a\u758f\u6c34\u6027\u3001\u4eb2\u6c34\u6027\u3001\u5e26\u7535\u6027\u4ee5\u53ca\u4f53\u79ef\u5927\u5c0f\u7b49\uff0c\u5e76\u8003\u8651\u6b8b\u57fa\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u800c\u5236\u8ba2\u51fa\u4e00\u5957\u9884\u6d4b\u89c4\u5219<\/strong>\u3002\u5bf9\u4e8e\u5c0f\u4e8e50\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u80bd\u94fe\uff0c Lim \u65b9\u6cd5\u7684\u9884\u6d4b<strong>\u51c6\u786e\u7387\u53ef\u4ee5\u8fbe\u523073%.<\/strong><br \/> <strong>Cohen \u65b9\u6cd5<\/strong>\uff0c\u5b83\u7684\u63d0\u51fa\u5f53\u65f6\u662f\u4e3a\u4e86\u03b1\/\u03b2\u86cb\u767d\u7684\u9884\u6d4b\uff0c<strong>\u57fa\u672c\u539f\u7406\u662f\u8bf4\uff1a\u758f\u6c34\u6027\u6b8b\u57fa\u51b3\u5b9a\u4e86\u4e8c\u7ea7\u7ed3\u6784\u7684\u76f8\u5bf9\u4f4d\u7f6e\uff0c\u87ba\u65cb\u4e9a\u5355\u5143\u6216\u6269\u5c55\u5355\u5143\u662f\u7ed3\u6784\u57df\u7684\u6838\u5fc3\uff0c\u03b1\u87ba\u65cb\u548c\u03b2\u6298\u53e0\u7ec4\u6210\u4e86\u7ed3\u6784\u57df\u3002<\/strong><br \/> <strong>\u6df7\u5408\u65b9\u6cd5\uff08hybrid system method\uff09:<\/strong><br \/> \u5c06\u4ee5\u4e0a\u51e0\u79cd\u65b9\u6cd5<strong>\u9009\u62e9\u6027\u7684\u6df7\u5408\u4f7f\u7528<\/strong>\uff0c<strong>\u5e76\u8c03\u6574\u4ed6\u4eec\u4e4b\u95f4\u4f7f\u7528\u7684\u6743\u91cd<\/strong>\u53ef\u4ee5\u63d0\u9ad8\u9884\u6d4b\u7684\u51c6\u786e\u7387\uff0c\u76ee\u524d<strong>\u9884\u6d4b\u51c6\u786e\u7387\u572870%\u4ee5\u4e0a<\/strong>\u7684\u90fd\u662f\u6df7\u5408\u65b9\u6cd5\uff0c<strong>\u5176\u4e2d\uff0c\u540c\u6e90\u6027\u6bd4\u8f83\u65b9\u6cd5\u3001\u795e\u7ecf\u7f51\u7edc\u65b9\u6cd5 \u548c GOR\u65b9\u6cd5 \u5e94\u7528\u6700\u4e3a\u5e7f\u6cdb\u3002<\/strong><\/p>\n<hr>\n<h2>\u4e8c. \u4e09\u7ea7\u7ed3\u6784\u7684\u9884\u6d4b<\/h2>\n<h3>\u540c\u6e90\u6027\u5efa\u6a21<\/h3>\n<p>\u5047\u8bbe\u5bf9\u5df2\u77e5\u7ed3\u6784\u7684\u53e6\u4e00\u4e2a\u86cb\u767d\u8d28\u5e8f\u5217\u6765\u6392\u5217\u4e00\u4e2a\u86cb\u767d\u8d28\u7684\u5e8f\u5217\uff0c<strong>\u5982\u679c\u9776\u5e8f\u5217\u548c\u5df2\u77e5\u7ed3\u6784\u5e8f\u5217\u5728\u6574\u4e2a\u5e8f\u5217\u7684\u5168\u957f\u6709\u5f88\u9ad8\u7684\u76f8\u4f3c\u6027\uff0c\u5728\u5408\u7406\u7684\u4fe1\u4efb\u5ea6\u4e0a\uff0c\u6211\u4eec\u53ef\u4ee5\u4f7f\u7528\u5df2\u77e5\u7ed3\u6784\u4f5c\u4e3a\u9776\u86cb\u767d\u8d28\u7684\u6a21\u7248\u3002<\/strong><\/p>\n<h3>\u201c\u4e32\u7ebf\uff08threading\uff09\u201d\u7b97\u6cd5<\/h3>\n<p><strong>\u4e32\u7ebf\u7ed3\u6784\u5206\u6790<\/strong>\u662f<strong>\u8bd5\u56fe\u628a\u672a\u77e5\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u548c\u5404\u79cd\u5df2\u5b58\u5728\u7684\u4e09\u7ef4\u7ed3\u6784\u76f8\u5339\u914d\uff0c\u5e76\u8bc4\u4f30\u5e8f\u5217\u6298\u53e0\u6210\u90a3\u79cd\u7ed3\u6784\u7684\u5408\u9002\u5ea6<\/strong>\u3002\u4e32\u7ebf\u6cd5<strong>\u6700\u9002\u7528\u4e8e\u6298\u53e0\uff08fold\uff09\u7684\u8bc6\u522b\uff0c\u800c\u4e0d\u662f\u6a21\u578b\u7684\u5efa\u7acb<\/strong>\u3002<br \/> \u5b83\u662f<strong>\u5feb\u901f\u7528\u672a\u77e5\u5e8f\u5217\u7684\u6c28\u57fa\u9178\u4fa7\u94fe\u66ff\u6362\u5df2\u77e5\u5e8f\u5217\u4e2d\u7684\u6c28\u57fa\u9178\u4f4d\u7f6e<\/strong>\u3002<br \/> Jones\u7b49<strong>\u9996\u5148\u4ece\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u5e93\u4e2d\u6311\u9009\u86cb\u767d\u8d28\u7ed3\u6784\u5efa\u7acb\u6298\u53e0\u5b50\u6570\u636e\u5e93\uff0c\u4ee5\u6298\u53e0\u5b50\u6570\u636e\u5e93\u4e2d\u7684\u6298\u53e0\u7ed3\u6784\u4f5c\u4e3a\u6a21\u677f\uff0c\u5c06\u76ee\u6807\u5e8f\u5217\u4e0e\u8fd9\u4e9b\u6a21\u677f\u4e00\u4e00\u5339\u914d\uff0c\u901a\u8fc7\u8ba1\u7b97\u6253\u5206\u51fd\u6570\u503c\u5224\u65ad\u5339\u914d\u7a0b\u5ea6\uff0c\u6839\u636e\u6253\u5206\u503c\u7ed9\u6a21\u677f\u7ed3\u6784\u6392\u5e8f\uff0c\u5176\u4e2d\u6253\u5206\u6700\u9ad8\u7684\u88ab\u8ba4\u4e3a\u662f\u76ee\u6807\u5e8f\u5217\u6700\u53ef\u80fd\u91c7\u53d6\u7684\u6298\u53e0\u7ed3\u6784<\/strong>\u3002<br \/> Threading \u65b9\u6cd5\u7684<strong>\u96be\u70b9\u5728\u4e8e\u5e8f\u5217\u4e0e\u6298\u53e0\u7ed3\u6784\u7684\u5339\u914d\u6280\u672f\u548c\u6253\u5206\u51fd\u6570\u7684\u786e\u5b9a<\/strong>\u3002\uff08Jones\u7b49\uff0c1992\uff09<\/p>\n<hr>\n<h2>\u4e09. \u86cb\u767d\u8d28\u4e8c\u7ea7\u7ed3\u6784\u9884\u6d4b<\/h2>\n<p>\u86cb\u767d\u8d28\u4e8c\u7ea7\u7ed3\u6784\u7684\u9884\u6d4b\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u86cb\u767d\u7ed3\u6784\u9884\u6d4b\u7684\u7b2c\u4e00\u6b65\uff0c\u662f\u6839\u636e\u5b83\u4eec\u88ab\u9884\u6d4b\u7684\u5c40\u90e8\u7ed3\u6784\uff0c\u5bf9\u86cb\u767d\u5e8f\u5217\u4e2d\u7684\u6c28\u57fa\u9178\u8fdb\u884c\u5206\u7c7b\u3002\u4e8c\u7ea7\u7ed3\u6784\u7684\u9884\u6d4b\u65b9\u6cd5\u901a\u5e38<strong>\u5206\u4e3a\u591a\u5e8f\u5217\u5217\u7ebf\u9884\u6d4b\u548c\u5355\u5e8f\u5217\u9884\u6d4b\u7684\u65b9\u6cd5<\/strong>\u3002<br \/> \u7531\u4e8e<strong>\u5355\u5e8f\u5217\u9884\u6d4b<\/strong>\u6240\u63d0\u4f9b\u7684\u4fe1\u606f\u53ea\u662f\u6b8b\u57fa\u7684\u987a\u5e8f\u800c\u6ca1\u6709\u5176\u7a7a\u95f4\u5206\u5e03\u7684\u4fe1\u606f\uff0c\u6240\u4ee5\u5355\u5e8f\u5217\u9884\u6d4b\u7684\u7b97\u6cd5<strong>\u9884\u6d4b\u51c6\u786e\u7387\u5e76\u4e0d\u9ad8\u800c\u4e14\u5bf9\u4e8e\u4e00\u4e9b\u7279\u6b8a\u7ed3\u6784\uff0c\u8fd9\u4e9b\u7b97\u6cd5\u5f88\u96be\u9884\u6d4b\u6210\u529f<\/strong>\u3002<br \/> <strong>\u591a\u5e8f\u5217\u5217\u7ebf\u9884\u6d4b<\/strong>\u548c<strong>\u795e\u7ecf\u7f51\u7edc<\/strong>\u7684\u5e94\u7528\u5927\u5927\u63d0\u9ad8\u4e86\u4e8c\u7ea7\u7ed3\u6784\u9884\u6d4b\u7684\u51c6\u786e\u5ea6\uff0c\u901a\u8fc7\u5bf9\u5e8f\u5217\u6bd4\u5bf9\u7684\u9884\u6d4b\u53ef\u4ee5\u660e\u786e\u7684\u63d0\u4f9b\u5355\u4e00\u4f4d\u70b9\u5728\u4e09\u7ef4\u7ed3\u6784\u4e0a\u7684\u4fe1\u606f\u3002\u8fd9\u6837\u901a\u5e38\u4e8c\u7ea7\u7ed3\u6784\u9884\u6d4b\u7684\u51c6\u786e\u7387\u6bd4\u5355\u5e8f\u5217<strong>\u9884\u6d4b\u80fd\u591f\u63d0\u9ad8\uff11\uff10%.\u8bb8\u591a\u65b9\u6cd5\u636e\u8bf4\u53ef\u8fbe\u523070%-77%<\/strong>\uff0c\u76ee\u524d\u8f83\u4e3a\u5e38\u7528\u7684\u51e0\u79cd<strong>\u65b9\u6cd5\u6709\uff1aPHD\u3001PSIPRED\u3001Jpred\u3001 PREDATOR\u3001PSA\u3002\u5176\u4e2d\u6700\u5e38\u7528\u7684\u662fPHD\u3002<\/strong><\/p>\n<p><strong>PHD\u7ed3\u5408\u4e86\u8bb8\u591a\u795e\u7ecf\u7f51\u7edc\u7684\u6210\u679c\uff0c\u6bcf\u4e2a\u7ed3\u679c\u90fd\u662f\u6839\u636e\u5c40\u90e8\u5e8f\u5217\u4e0a\u4e0b\u6587\u5173\u7cfb\u548c\u6574\u4f53\u86cb\u767d\u8d28\u6027\u8d28\uff08\u86cb\u767d\u8d28\u957f\u5ea6\u3001\u6c28\u57fa\u9178\u9891\u7387\u7b49\uff09\u6765\u9884\u6d4b\u6b8b\u57fa\u7684\u4e8c\u7ea7\u7ed3\u6784<\/strong>\u3002\u90a3\u4e48\uff0c<strong>\u6700\u7ec8\u7684\u9884\u6d4b\u662f\u8fd9\u4e9b\u795e\u7ecf\u7f51\u7edc\u6bcf\u4e2a\u8f93\u51fa\u7684\u7b97\u672f\u5e73\u5747\u503c<\/strong>\u3002 \u8fd9\u79cd\u7ed3\u5408\u65b9\u6848\u88ab\u79f0\u4e3a<strong>\u966a\u5ba1\u56e2\u51b3\u5b9a\u6cd5<\/strong>\uff08jury decision\uff09\u6216\u8005\u79f0\u4e3a\u6240\u6709<strong>\u80dc\u5229\u8005\uff08winner-take-all\uff09\u6cd5<\/strong>\u3002<\/p>\n<h3><strong>PHD\u88ab\u8ba4\u4e3a\u662f\u4e8c\u7ea7\u7ed3\u6784\u9884\u6d4b\u7684\u6807\u51c6\u3002<\/strong><\/h3>\n<hr>\n<h2>\u56db. \u86cb\u767d\u8d28\u4e09\u7ea7\u7ed3\u6784\u9884\u6d4b<\/h2>\n<p>\u86cb\u767d\u8d28\u4e09\u7ef4\u7ed3\u6784\u7684<strong>\u9884\u6d4b\u65b9\u6cd5\u901a\u5e38\u5305\u62ec\uff1a\u540c\u6e90\u6027\u5efa\u6a21\u548c\u4ece\u5934\u5f00\u59cb\u7684\u9884\u6d4b\u65b9\u6cd5<\/strong>\u3002\u5bf9\u6570\u636e\u5e93\u4e2d\u5df2\u77e5\u7ed3\u6784\u7684\u5e8f\u5217\u7684\u6bd4\u5bf9\u662f\u9884\u6d4b\u672a\u77e5\u5e8f\u5217\u4e09\u7ea7\u7ed3\u6784\u7684\u4e3b\u8981\u65b9\u6cd5\uff0c\u4e5f\u5373\u540c\u6e90\u5efa\u6a21\u7684\u65b9\u6cd5\u3002<br \/> <strong>\u901a\u5e38\u5bf9\u4e8e\u540c\u6e90\u5efa\u6a21\u7684\u65b9\u6cd5\u8fc7\u7a0b\u5e76\u975e\u7edf\u4e00\uff0c\u4f46\u57fa\u672c\u601d\u8def\u662f\u4e00\u81f4\u7684\uff0c\u57fa\u672c\u5305\u62ec\u5982\u4e0b\u51e0\u4e2a\u6b65\u9aa4\uff1a<br \/> 1\uff0e\u4f7f\u7528\u672a\u77e5\u5e8f\u5217\u4f5c\u4e3a\u67e5\u8be2\u6765\u641c\u7d22\u5df2\u77e5\u86cb\u767d\u8d28\u7ed3\u6784\u3002<br \/> 2\uff0e\u4ea7\u751f\u672a\u77e5\u5e8f\u5217\u548c\u6a21\u7248\u5e8f\u5217\u6700\u53ef\u80fd\u7684\u5b8c\u6574\u6bd4\u5bf9\u3002<br \/> 3\uff0e\u4ee5\u6a21\u7248\u7ed3\u6784\u9aa8\u67b6\u4f5c\u4e3a\u6a21\u578b\uff0c\u5efa\u7acb\u86cb\u767d\u8d28\u9aa8\u67b6\u6a21\u578b\u3002<br \/> 4\uff0e\u5728\u9776\u5e8f\u5217\u6216\u8005\u6a21\u7248\u5e8f\u5217\u7684\u6709\u7a7a\u4f4d\u533a\u57df\uff0c\u4f7f\u7528\u73af\u5efa\u6a21\u8fc7\u7a0b\u4ee3\u66ff\u5408\u9002\u957f\u5ea6\u7684\u7247\u6bb5\u3002<br \/> 5\uff0e\u7ed9\u9aa8\u67b6\u6a21\u578b\u52a0\u4e0a\u4fa7\u94fe\u3002<br \/> 6\uff0e\u4f18\u5316\u4fa7\u94fe\u7684\u4f4d\u7f6e\u3002<br \/> 7\uff0e\u4f7f\u7528\u80fd\u91cf\u6700\u5c0f\u548c\u5df2\u77e5\u7684\u4f18\u5316\u77e5\u8bc6\u6765\u4f18\u5316\u7ed3\u6784\u3002<\/strong><\/p>\n<p>\u5728\u8fdb\u884c\u5e8f\u5217\u6bd4\u5bf9\u65f6\uff0c\u6700\u5bb9\u6613\u4f7f\u7528 BLASTP \u7a0b\u5e8f\u6bd4\u5bf9 NRL-3D \u6216 SCOP \u6570\u636e\u5e93\u4e2d\u7684\u5e8f\u5217\u3002\u5982\u679c\u53d1\u73b0<strong>\u8d85\u8fc7100\u4e2a\u78b1\u57fa\u957f\u5ea6\u4e14\u6709\u8fdc\u9ad8\u4e8e40%\u5e8f\u5217\u76f8\u540c\u7387\u7684\u5339\u914d\u5e8f\u5217\uff0c\u5219\u672a\u77e5\u5e8f\u5217\u86cb\u767d\u4e0e\u8be5\u5339\u914d\u5e8f\u5217\u86cb\u767d\u5c06\u6709\u975e\u5e38\u76f8\u4f3c\u7684\u7ed3\u6784<\/strong>\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u540c\u6e90\u6027\u5efa\u6a21\u5728\u9884\u6d4b\u8be5\u672a\u77e5\u86cb\u767d\u7cbe\u7ec6\u7ed3\u6784\u65b9\u9762\u4f1a\u6709\u975e\u5e38\u5927\u7684\u4f5c\u7528\u3002<br \/> \u540c\u6e90\u6027\u5efa\u6a21\u7684<strong>\u6210\u529f\u7684\u5173\u952e\u901a\u5e38\u4e0d\u662f\u5efa\u6a21\u4f7f\u7528\u7684\u8f6f\u4ef6\u6216\u670d\u52a1\u5668\uff0c\u5728\u8bbe\u8ba1\u4e0e\u6a21\u7248\u7ed3\u6784\u597d\u7684\u6bd4\u5bf9\u65f6\u7684\u6280\u5de7\u66f4\u52a0\u91cd\u8981<\/strong>\u3002<br \/> <img decoding=\"async\" src=\"https:\/\/img.mushiming.top\/app\/mushiming_com\/3a5beae7c712445b9295b0a3927df326.jpg\" =\"\" =\"\u86cb\u767d\u8d28\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u6570\u76ee\" alt=\"\u86cb\u767d\u8d28\u7ed3\u6784\u4e0e\u529f\u80fd\u7684\u9884\u6d4b\u65b9\u6cd5\u603b\u7ed3\u548c\u8d44\u6599\u6c47\u603b (https:\/\/mushiming.com\/)  \u7b2c2\u5f20\" title=\"\u86cb\u767d\u8d28\u7ed3\u6784\u4e0e\u529f\u80fd\u7684\u9884\u6d4b\u65b9\u6cd5\u603b\u7ed3\u548c\u8d44\u6599\u6c47\u603b  \u7b2c2\u5f20-\u7a46\u4e16\u660e\u535a\u5ba2\" ><\/p>\n<hr>\n<h2>\u4e94. \u5e38\u7528\u86cb\u767d\u5e8f\u5217\u548c\u7ed3\u6784\u6570\u636e\u5e93<\/h2>\n<p>\u6570\u636e\u5e93\u8bf4\u660e\u7f51\u5740\u94fe\u63a5<br \/> <strong>PDB\u86cb\u767d\u8d28\u4e09\u7ef4\u7ed3\u6784<\/strong>http:\/\/www.rcsb.org\/pdb<br \/> <strong>SWISS-PROT\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u5e93<\/strong>http:\/\/kr.expasy.org\/sprot\/<br \/> <strong>PIR\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u5e93<\/strong>http:\/\/pir.georgetown.edu\/<br \/> <strong>OWL\u975e\u5197\u4f59\u86cb\u767d\u8d28\u5e8f\u5217<\/strong>http:\/\/www.bioinf.man.ac.uk\/dbbrowser\/OWL\/<br \/> <strong>EMBL\u6838\u9178\u5e8f\u5217\u6570\u636e\u5e93<\/strong>http:\/\/www.embl-heidelberg.de\/<br \/> <strong>TrEMBLEMBL\u7684\u7ffb\u8bd1\u6570\u636e\u5e93<\/strong>http:\/\/kr.expasy.org\/sprot\/<br \/> <strong>GenBANK\u6838\u9178\u5e8f\u5217\u6570\u636e\u5e93<\/strong>http:\/\/www.ncbi.nih.gov\/Genbank\/<br \/> <strong>PROSITE\u86cb\u767d\u8d28\u529f\u80fd\u4f4d\u70b9<\/strong>http:\/\/kr.expasy.org\/prosite\/<br \/> <strong>SWISS-MODEL\u4ece\u5e8f\u5217\u6a21\u5efa\u7ed3\u6784<\/strong>http:\/\/www.expasy.org\/swissmod\/SWISS-MODEL.html<br \/> <strong>SWISS-3DIMAGE\u4e09\u7ef4\u7ed3\u6784\u56fe\u793a<\/strong>http:\/\/us.expasy.org\/sw3d\/<br \/> <strong>DSSP\u86cb\u767d\u8d28\u4e8c\u7ea7\u7ed3\u6784\u53c2\u6570<\/strong>http:\/\/www.cmbi.kun.nl\/gv\/dssp\/<br \/> <strong>FSSP\u5df2\u77e5\u7a7a\u95f4\u7ed3\u6784\u7684\u86cb\u767d\u8d28\u5bb6\u65cf<\/strong>http:\/\/www.ebi.ac.uk\/dali\/fssp\/fssp.html<br \/> <strong>SCOP\u86cb\u767d\u8d28\u5206\u7c7b\u6570\u636e\u5e93<\/strong>http:\/\/scop.mrc-lmb.cam.ac.uk\/scop\/<br \/> <strong>CATH\u86cb\u767d\u8d28\u5206\u7c7b\u6570\u636e\u5e93<\/strong>http:\/\/www.biochem.ucl.ac.uk\/bsm\/cath\/<br \/> <strong>Pfam\u86cb\u767d\u8d28\u5bb6\u65cf\u548c\u7ed3\u6784\u57df<\/strong>http:\/\/pfam.wustl.edu\/**<\/p>\n<h3>\uff08\u4e00\uff09\u86cb\u767d\u8d28\u4e00\u7ea7\u6570\u636e\u5e93<\/h3>\n<p><strong>1\u3001 SWISS-PROT \u6570\u636e\u5e93<\/strong><\/p>\n<p>SWISS-PROT\u548cPIR\u662f\u56fd\u9645\u4e0a\u4e8c\u4e2a\u4e3b\u8981\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u5e93\uff0c\u76ee\u524d\u8fd9\u4e8c\u4e2a\u6570\u636e\u5e93\u5728EMBL\u548cGenBank\u6570\u636e\u5e93\u4e0a\u5747\u5efa\u7acb\u4e86\u955c\u50cf (mirror) \u7ad9\u70b9\u3002<\/p>\n<p>SWISS-PROT\u6570\u636e\u5e93\u5305\u62ec\u4e86\u4eceEMBL\u7ffb\u8bd1\u800c\u6765\u7684\u86cb\u767d\u8d28\u5e8f\u5217\uff0c\u8fd9\u4e9b\u5e8f\u5217\u7ecf\u8fc7\u68c0\u9a8c\u548c\u6ce8\u91ca\u3002\u8be5\u6570\u636e\u5e93\u4e3b\u8981\u7531\u65e5\u5185\u74e6\u5927\u5b66\u533b\u5b66\u751f\u7269\u5316\u5b66\u7cfb\u548c\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u6240(EBI)\u5408\u4f5c\u7ef4\u62a4\u3002SWISS-PROT\u7684\u5e8f\u5217\u6570\u91cf\u5448\u76f4\u7ebf\u589e\u957f\u3002<\/p>\n<p><strong>2\u3001TrEMBL\u6570\u636e\u5e93<\/strong><\/p>\n<p>SWISS-PROT\u7684\u6570\u636e\u5b58\u5728\u4e00\u4e2a\u6ede\u540e\u95ee\u9898\uff0c\u5373\u628aEMBL\u7684DNA\u5e8f\u5217\u51c6\u786e\u5730\u7ffb\u8bd1\u6210\u86cb\u767d\u8d28\u5e8f\u5217\u5e76\u8fdb\u884c\u6ce8\u91ca\u9700\u8981\u65f6\u95f4\u3002\u4e00\u5927\u6279\u542b\u6709\u5f00\u653e\u9605\u8bfb\u6846(ORF) \u7684DNA\u5e8f\u5217\u5c1a\u672a\u5217\u5165SWISS-PROT\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0cTrEMBL(Translated EMBL) \u6570\u636e\u5e93\u88ab\u5efa\u7acb\u4e86\u8d77\u6765\u3002TrEMBL\u4e5f\u662f\u4e00\u4e2a\u86cb\u767d\u8d28\u6570\u636e\u5e93\uff0c\u5b83\u5305\u62ec\u4e86\u6240\u6709EMBL\u5e93\u4e2d\u7684\u86cb\u767d\u8d28\u7f16\u7801\u533a\u5e8f\u5217\uff0c\u63d0\u4f9b\u4e86\u4e00\u4e2a\u975e\u5e38\u5168\u9762\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u6e90\uff0c\u4f46\u8fd9\u52bf\u5fc5\u5bfc\u81f4\u5176\u6ce8\u91ca\u8d28\u91cf\u7684\u4e0b\u964d\u3002<\/p>\n<p><strong>3\u3001PIR\u6570\u636e\u5e93<\/strong><\/p>\n<p>PIR\u6570\u636e\u5e93\u7684\u6570\u636e\u6700\u521d\u662f\u7531\u7f8e\u56fd\u56fd\u5bb6\u751f\u7269\u533b\u5b66\u7814\u7a76\u57fa\u91d1\u4f1a\uff08National Biomedical Research Foundation, NBRF\uff09\u6536\u96c6\u7684\u86cb\u767d\u8d28\u5e8f\u5217\uff0c\u4e3b\u8981\u7ffb\u8bd1\u81eaGenBank\u7684DNA\u5e8f\u5217\u3002<\/p>\n<p>1988\u5e74\uff0c\u7f8e\u56fd\u7684NBRF\u3001\u65e5\u672c\u7684JIPID\uff08the Japanese International Protein Sequence Database\u65e5\u672c\u56fd\u5bb6\u86cb\u767d\u8d28\u4fe1\u606f\u6570\u636e\u5e93\uff09\u3001\u5fb7\u56fd\u7684MIPS\uff08Munich Information Centre for Protein Sequences\u6479\u5c3c\u9ed1\u86cb\u767d\u8d28\u5e8f\u5217\u4fe1\u606f\u4e2d\u5fc3\uff09\u5408\u4f5c\uff0c\u5171\u540c\u6536\u96c6\u548c\u7ef4\u62a4PIR\u6570\u636e\u5e93\u3002PIR\u6839\u636e\u6ce8\u91ca\u7a0b\u5ea6(\u8d28\u91cf)\u5206\u4e3a4\u4e2a\u7b49\u7ea7\u3002<\/p>\n<p><strong>4\u3001 ExPASy\u6570\u636e\u5e93<\/strong><\/p>\n<p>\u76ee\u524d\uff0c\u745e\u58eb\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u6240\uff08Swiss Institute of Bioinformatics, SIB\uff09\u521b\u5efa\u4e86\u86cb\u767d\u8d28\u5206\u6790\u4e13\u5bb6\u7cfb\u7edf\uff08Expert protein analysis system, ExPASy \uff09\u3002\u6db5\u76d6\u4e86\u4e0a\u8ff0\u6240\u6709\u7684\u6570\u636e\u5e93\u3002<\/p>\n<p>\u7f51\u5740\uff1ahttp:\/\/www.expasy.org<\/p>\n<p>\u6211\u56fd\u7684\u5317\u4eac\u5927\u5b66\u751f\u7269\u4fe1\u606f\u4e2d\u5fc3(www.cbi.pku.edu.cn) \u8bbe\u7acb\u4e86ExPASy\u7684\u955c\u50cf\uff08Mirror\uff09\u3002<\/p>\n<h3>\uff08\u4e8c\uff09\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u5e93<\/h3>\n<p><strong>1\u3001PDB\u6570\u636e\u5e93<\/strong><\/p>\n<p>\u5b9e\u9a8c\u83b7\u5f97\u7684\u4e09\u7ef4\u86cb\u767d\u8d28\u7ed3\u6784\u5747\u8d2e\u5b58\u5728\u86cb\u767d\u8d28\u6570\u636e\u5e93PDB(Protein Data Bank)\u4e2d\u3002PDB\u662f\u56fd\u9645\u4e0a\u4e3b\u8981\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u5e93\uff0c\u867d\u7136\u5b83\u6ca1\u6709\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u5e93\u90a3\u4e48\u5e9e\u5927\uff0c\u4f46\u5176\u589e\u957f\u901f\u5ea6\u5f88\u5feb\u3002PDB\u8d2e\u5b58\u6709\u7531X\u5c04\u7ebf\u548c\u6838\u78c1\u5171\u632f(NMR)\u786e\u5b9a\u7684\u7ed3\u6784\u6570\u636e\u3002<\/p>\n<p><strong>2\u3001NRL-3D \u6570\u636e\u5e93<\/strong><\/p>\n<p>NRL-3D\uff08Naval Research Laboratory-3D\uff09\u6570\u636e\u5e93\u63d0\u4f9b\u4e86\u8d2e\u5b58\u5728PDB\u5e93\u4e2d\u86cb\u767d\u8d28\u7684\u5e8f\u5217\uff0c\u5b83\u53ef\u4ee5\u8fdb\u884c\u4e0e\u5df2\u77e5\u7ed3\u6784\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u6bd4\u8f83\u3002<\/p>\n<p><strong>3\u3001HSSP\u6570\u636e\u5e93<\/strong><\/p>\n<p>\u5bf9\u6765\u81eaPDB\u4e2d\u6bcf\u4e2a\u5df2\u77e5\u4e09\u7ef4\u7ed3\u6784\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u8fdb\u884c\u591a\u5e8f\u5217\u5217\u7ebf(multiple sequence alignment)\u540c\u6e90\u6027\u6bd4\u8f83\u7684\u7ed3\u679c\uff0c\u88ab\u8d2e\u5b58\u5728HSSP(homology-derived second structures of proteins)\u6570\u636e\u5e93\u4e2d\u3002\u88ab\u5217\u4e3a\u540c\u6e90\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u5f88\u6709\u53ef\u80fd\u5177\u6709\u76f8\u540c\u7684\u4e09\u7ef4\u7ed3\u6784\uff0cHSSP\u56e0\u6b64\u6839\u636e\u540c\u6e90\u6027\u7ed9\u51fa\u4e86SWISS-PROT\u6570\u636e\u5e93\u4e2d\u6240\u6709\u86cb\u767d\u8d28\u5e8f\u5217\u6700\u6709\u53ef\u80fd\u7684\u4e09\u7ef4\u7ed3\u6784\u3002<\/p>\n<p><strong>4\u3001 SCOP\u6570\u636e\u5e93<\/strong><\/p>\n<p>\u8981\u60f3\u4e86\u89e3\u5bf9\u5df2\u77e5\u7ed3\u6784\u86cb\u767d\u8d28\u8fdb\u884c\u7b49\u7ea7\u5206\u7c7b\u7684\u60c5\u51b5\u53ef\u5229\u7528SCOP(Structural classification of proteins)\u6570\u636e\u5e93\uff0c\u5728\u8be5\u5e93\u4e2d\u53ef\u4ee5\u6bd4\u8f83\u67d0\u4e00\u86cb\u767d\u8d28\u4e0e\u5df2\u77e5\u7ed3\u6784\u86cb\u767d\u7684\u7ed3\u6784\u76f8\u4f3c\u6027\u3002<\/p>\n<p><strong>5\u3001 CATH \u6570\u636e\u5e93<\/strong><\/p>\n<p>CATH(Class, Architecture, Topology and Homologous superfamily)\u662f\u4e0eSCOP\u7c7b\u4f3c\u7684\u4e00\u4e2a\u6570\u636e\u5e93\u3002<\/p>\n<h2>\u516d. \u7ed3\u6784\u9884\u6d4b\u76f8\u5173\u7a0b\u5e8f\u53ca\u6570\u636e\u5e93<\/h2>\n<p>\u86cb\u767d\u8d28\u9884\u6d4b\u5206\u6790\u7f51\u5740\u96c6\u9526<\/p>\n<p><strong>\u7269\u7406\u6027\u8d28\u9884\u6d4b<\/strong><br \/> Compute PI\/MW http:\/\/expaxy.hcuge.ch\/ch2d\/pi-tool.html<br \/> Peptidemasshttp:\/\/expaxy.hcuge.ch\/sprot\/peptide-mass.html TGREASE ftp:\/\/ftp.virginia.edu\/pub\/fasta\/<br \/> SAPS http:\/\/ulrec3.unil.ch\/software\/SAPS_form.html<\/p>\n<p><strong>\u57fa\u4e8e\u7ec4\u6210\u7684\u86cb\u767d\u8d28\u8bc6\u522b\u9884\u6d4b<\/strong><br \/> AACompIdent http:\/\/expaxy.hcuge.ch \u2026 htmlAACompSim http:\/\/expaxy.hcuge.ch\/ch2d\/aacsim.html PROPSEARCH http:\/\/www.embl-heidelberg.de\/prs.html<\/p>\n<p><strong>\u4e8c\u7ea7\u7ed3\u6784\u548c\u6298\u53e0\u7c7b\u9884\u6d4b<\/strong><br \/> nnpredict http:\/\/www.cmpharm.ucsf.edu\/~nomi\/nnpredict<br \/> Predictprotein http:\/\/www.embl-heidel \u2026 protein\/SOPMA http:\/\/www.ibcp.fr\/predict.html<br \/> SSPRED http:\/\/www.embl-heidel \u2026 prd_info.html<\/p>\n<p><strong>\u7279\u6b8a\u7ed3\u6784\u6216\u7ed3\u6784\u9884\u6d4b<\/strong><br \/> COILS http:\/\/ulrec3.unil.ch\/ \u2026 ILS_form.html<br \/> MacStripe http:\/\/www.wi.mit.edu\/ \u2026 acstripe.html<\/p>\n<p>\u86cb\u767d\u8d28\u9884\u6d4b\u5728\u7ebf\u5206\u6790\u5e38\u7528\u8f6f\u4ef6\u96c6\u9526<\/p>\n","protected":false},"excerpt":{"rendered":"\u86cb\u767d\u8d28\u7ed3\u6784\u4e0e\u529f\u80fd\u7684\u9884\u6d4b\u65b9\u6cd5\u603b\u7ed3\u548c\u8d44\u6599\u6c47\u603b\u8f6c\u8f7d_expertproteinanalysissystem","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"_links":{"self":[{"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/posts\/8979"}],"collection":[{"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/comments?post=8979"}],"version-history":[{"count":0,"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/posts\/8979\/revisions"}],"wp:attachment":[{"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/media?parent=8979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/categories?post=8979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mushiming.com\/wp-json\/wp\/v2\/tags?post=8979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}